Estudios clínicos

Evaluation of the efficacy of a topical sialogogue spray containing malic acid 1% in elderly people with xerostomia: a double-blind, randomized clinical trial

Evaluation of the efficacy of a topical sialogogue spray containing malic acid 1% in elderly people with xerostomia: a double-blind, randomized clinical trial
Autores: Gerardo Gómez-Moreno, Maribel Cabrera-Ayala, Antonio Aguilar-Salvatierra, Javier Guardia, María Piedad Ramírez-Fernández, Máximino González-Jaranay, José Luis Calvo-Guirado
Publicado en: Gerodontology
Más info: http://www.ncbi.nlm.nih.gov/pubmed/23294350

DESCRIPCIÓN

Objective: 

The aim of this study was to evaluate the clinical efficacy of a topical sialogogue spray con- taining 1% malic acid for elderly people affected by xerostomia. 

Material and methods:

This research took the form of a double-blind, randomized clinical trial. Forty- one individuals (mean age: 78.7 years) with xerostomia were divided into two groups: for the first ‘intervention group’ (21 subjects) a topical sialogogue spray (1% malic acid) was applied, while for the second ‘control group’ (20 subjects), a placebo spray was applied; for both groups, the sprays were applied on demand during 2 weeks. The Xerostomia Inventory (XI) was used to evaluate xerostomia levels before and after product/placebo application. Unstimulated and stimulated salivary flows rates, before and after spray application, were measured.

Results: 

XI scores decreased significantly (clinically meaningful) from 36.4 7.3 points to 29.1 7.1 (p < 0.05) with an XI difference of 7.2 6.1, after the combination among 1% malic acid with xylitol and fluoride application. After 2 weeks of 1% malic acid application, unstimulated and stimulated sali- vary flows rates increased significantly (p < 0.05).

Conclusion: 

A topical sialogogue spray containing 1% malic acid improved xerostomia in an elderly population and increased unstimulated and stimulated salivary flows rates

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