Estudios clínicos

Evaluation of Cetyl-Pyridinium Chloride Formulations In Orthodontic Patients: Periodontal Outcomes

DESCRIPCIÓN

Objectives: 

To assess the clinical and microbiological effects of the use of a cetylpyridinium chloride (CPC) toothpaste and mouth rinse in patients with fixed orthodontic devices. 

Methods: 

In this randomized clinical trial, 31 patients were assigned to brush and rinse with placebo products and 32 with the test products (Vitis Orthodontic®). After screening, patients received a baseline examination, a prophylaxis and then were re- assessed monthly for 3 months. Plaque (PlI) and gingival (GI) indices were evaluated. Subgingival pooled microbiological samples were taken at baseline and after 3 months, and processed by culture. Clinical variables were compared by paired or unpaired t- test, and microbiological variables by non-parametric tests.

Results: 

After 3 months, results from 23 placebo and 27 test patients were available. After 1 month, placebo patients showed significantly higher GI (p=0.02), and that was also true after 3 months (p=0.05). In interdental PlI, after 1 month, the placebo group increased 0.19 (SD 0.56) while the test group decreased 0.07 (SD 0.66), showing a tendency towards significance (p=0.09). Differences in plaque change baseline-1 month were significant when considering the upper jaw alone (p=0.02). Non-significant minor changes were observed in microbiological parameters, and no overgrowth of opportunistic species was detected.

Conclusion:

The use of CPC-based toothpaste and a mouthrinse may help to reduce plaque accumulation and gingival inflammation in orthodontic patients, although the effectsare of limited magnitude and with wide variability. No adverse microbiological effects are associated to 3 months of use.

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